Overexpression of IL-13 in AD Skin

IL-13 was found to be overexpressed in AD skin.1,3

IL-13 overexpression in AD Skin as shown in mRNA expression1

No or limited IL-4 mRNA expression detected1

 

Data derived from online supplement in the reference
*P<0.01 vs control; † P<0.0001 vs control

 

Adapted from Tsoi LC, et al.1

Both IL-13 and IL-4 levels are elevated in AD lesional skin compared to healthy controls, in these studies IL-13 levels are higher than IL-4 levels, and IL-4 is frequently undetectable1,2,3

In this study IL-13 overexpression in AD skin as shown in lesional skin-tape strips2

No or limited IL-4 protein levels detected in lesional skin-tape strips2

Table created by ADKeySuspect.com highlighting a study of skin samples taken from 90 patients with atopic dermatitis and 20 healthy controls to assess protein levels in lesional skin using a skin–tape stripping methodology; the data demonstrated high levels of IL-13 in all skin samples and low or undetectable IL-4 levels

Adapted from Koppes et al.2

  • IL-4 was detected in 41/90 (46%) patients2

    • In this study, skin samples were taken from 90 patients with AD and 20 healthy controls to assess protein levels in lesional skin using skin-tape-stripping methodology: the study demonstrated high levels of IL-13 in all skin samples and low or undetectable IL-4 levels2

In this study results show that IL-13 is overexpressed in lesional skin, whereas IL-4 is detectable only at low levels or undetectable.1-3

Current evidence demonstrates that IL-13 is overexpressed in AD skin1-3. Strong correlations are seen between AD clinical disease severity and IL-13 expression levels in lesional and non-lesional AD skin.1-3

See how IL-13 correlates with severity

  1. Tsoi LC, Rodriguez E, Degenhardt F, et al. Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis. J Invest Dermatol. 2019;139(7):1480-1489.
  2. Koppes SA, Brans R, Ljubojevic Hadzavdic S, Frings-Dresen MH, Rustemeyer T, Kezic S. Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy. Int Arch Allergy Immunol. 2016;170(3):187-193.
  3. Szegedi K, Lutter R, Res PC, et al. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin. J Eur Acad Dermatol Venereol. 2015;29(11):2136-2144.